Two sample MR report

Telomere_length against wg lh intensity-contrast parsopercularis

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0757835	0.1414824	0.5978358
Weighted median	23	-0.1640563	0.0669207	0.0142261
Inverse variance weighted	23	-0.1724471	0.0547207	0.0016249
Simple mode	23	-0.1971966	0.1104116	0.0878893
Weighted mode	23	-0.2014975	0.1281124	0.1300331

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.54412	21	0.0035923
Inverse variance weighted	43.66023	22	0.0039100

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059352	0.0079963	0.4661643

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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