Two sample MR report

Telomere_length against wg lh intensity-contrast parahippocampal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0496117	0.1306844	0.7080320
Weighted median	23	-0.1548178	0.0635514	0.0148464
Inverse variance weighted	23	-0.1514165	0.0507374	0.0028421
Simple mode	23	-0.3533821	0.1198436	0.0074251
Weighted mode	23	-0.1448039	0.0986262	0.1562009

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.29556	21	0.020251
Inverse variance weighted	37.53346	22	0.020656

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062508	0.007386	0.4069241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015977	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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