Two sample MR report

Telomere_length against wg lh intensity-contrast paracentral

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1850962	0.1379092	0.1938759
Weighted median	23	-0.1105272	0.0573360	0.0538912
Inverse variance weighted	23	-0.1152308	0.0530307	0.0297872
Simple mode	23	-0.1503589	0.0936450	0.1226157
Weighted mode	23	-0.0986612	0.0625031	0.1287227

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.41937	21	0.0066100
Inverse variance weighted	41.00237	22	0.0082357

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042897	0.0077943	0.587876

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001509	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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