Two sample MR report

Telomere_length against wg lh intensity-contrast middletemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0321108	0.1453956	0.8273412
Weighted median	23	-0.1911778	0.0649675	0.0032540
Inverse variance weighted	23	-0.1928037	0.0573846	0.0007798
Simple mode	23	-0.2218105	0.1077028	0.0514770
Weighted mode	23	-0.2144256	0.1052190	0.0537617

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.92992	21	0.0017690
Inverse variance weighted	48.01433	22	0.0010803

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0098665	0.0082174	0.2432432

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002201	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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