Two sample MR report

Telomere_length against wg lh intensity-contrast medialorbitofrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1670344	0.1238620	0.1918458
Weighted median	23	-0.1404263	0.0614588	0.0223197
Inverse variance weighted	23	-0.1572501	0.0472974	0.0008851
Simple mode	23	-0.0820922	0.1239801	0.5147585
Weighted mode	23	-0.0963633	0.0883229	0.2870632

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.60585	21	0.0507745
Inverse variance weighted	32.61729	22	0.0674641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006008	0.0070005	0.9324243

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014848	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8