Two sample MR report

Telomere_length against wg lh intensity-contrast lingual

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0030550	0.1505673	0.9840036
Weighted median	23	-0.1237206	0.0608373	0.0419890
Inverse variance weighted	23	-0.1289011	0.0587128	0.0281313
Simple mode	23	-0.2312958	0.1145563	0.0558308
Weighted mode	23	-0.1385769	0.0872296	0.1264094

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.18089	21	0.0006497
Inverse variance weighted	50.26068	22	0.0005407

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081021	0.0085097	0.351878

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018565	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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