Two sample MR report

Telomere_length against wg lh intensity-contrast lateralorbitofrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0754101	0.1471549	0.6136813
Weighted median	23	-0.2145485	0.0637077	0.0007580
Inverse variance weighted	23	-0.1672808	0.0567942	0.0032255
Simple mode	23	-0.2422082	0.1266132	0.0688553
Weighted mode	23	-0.2206271	0.1111551	0.0597686

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.02161	21	0.0012694
Inverse variance weighted	47.02973	22	0.0014546

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056409	0.008317	0.5050237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019868	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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