Two sample MR report

Telomere_length against wg lh intensity-contrast lateraloccipital

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0110264	0.1355947	0.9359584
Weighted median	23	-0.2043122	0.0656107	0.0018456
Inverse variance weighted	23	-0.1689324	0.0542709	0.0018535
Simple mode	23	-0.3247259	0.1196149	0.0126521
Weighted mode	23	-0.2253103	0.0949621	0.0268258

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.07661	21	0.0096106
Inverse variance weighted	42.94494	22	0.0047933

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0110495	0.0076636	0.1640991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018743	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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