Two sample MR report

Telomere_length against wg lh intensity-contrast isthmuscingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0747949	0.1334666	0.5811355
Weighted median	23	-0.0886326	0.0643383	0.1683258
Inverse variance weighted	23	-0.1025892	0.0534259	0.0548308
Simple mode	23	-0.1872667	0.1386384	0.1905041
Weighted mode	23	-0.0867342	0.0877582	0.3337362

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.85699	21	0.0133948
Inverse variance weighted	41.61516	22	0.0069564

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108914	0.0075432	0.1635325

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014723	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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