Two sample MR report

Telomere_length against wg lh intensity-contrast insula

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0279127	0.1658520	0.8679584
Weighted median	23	-0.1682294	0.0657003	0.0104504
Inverse variance weighted	23	-0.1699768	0.0646131	0.0085212
Simple mode	23	-0.1262252	0.1132958	0.2772516
Weighted mode	23	-0.1414031	0.0937698	0.1457866

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	58.46158	21	2.18e-05
Inverse variance weighted	60.87229	22	1.66e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0087227	0.0093736	0.3626542

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024243	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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