Two sample MR report

Telomere_length against wg lh intensity-contrast inferiortemporal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0807071	0.1470500	0.5889028
Weighted median	23	-0.1901174	0.0625204	0.0023588
Inverse variance weighted	23	-0.1876829	0.0569715	0.0009866
Simple mode	23	-0.2145788	0.1095760	0.0629988
Weighted mode	23	-0.1846815	0.0739862	0.0205385

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.95780	21	0.0012944
Inverse variance weighted	47.32473	22	0.0013311

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065683	0.0083109	0.4381744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021409	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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