Two sample MR report

Telomere_length against wg lh intensity-contrast inferiorparietal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0569365	0.1387761	0.6857590
Weighted median	23	-0.2732463	0.0639995	0.0000196
Inverse variance weighted	23	-0.2141522	0.0548612	0.0000948
Simple mode	23	-0.2908589	0.1085578	0.0136996
Weighted mode	23	-0.2833913	0.1070892	0.0147472

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.93217	21	0.0057164
Inverse variance weighted	43.88456	22	0.0036663

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0096531	0.0078433	0.2320298

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022506	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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