Two sample MR report

Telomere_length against wg lh intensity-contrast fusiform

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0215096	0.1415715	0.8806888
Weighted median	23	-0.1687976	0.0639821	0.0083347
Inverse variance weighted	23	-0.1737640	0.0557797	0.0018383
Simple mode	23	-0.2411217	0.1155377	0.0486919
Weighted mode	23	-0.1637238	0.0979367	0.1087420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.59611	21	0.0035382
Inverse variance weighted	45.36499	22	0.0023848

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093484	0.0080013	0.2557547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8