Two sample MR report

Telomere_length against wg lh intensity-contrast frontalpole

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1518328	0.1146948	0.1998007
Weighted median	23	-0.0807478	0.0583297	0.1662560
Inverse variance weighted	23	-0.1456544	0.0437925	0.0008810
Simple mode	23	-0.0245820	0.1164147	0.8347069
Weighted mode	23	-0.0310753	0.0842380	0.7157295

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.95643	21	0.1413915
Inverse variance weighted	27.96099	22	0.1769778

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003794	0.0064824	0.9538869

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8