Two sample MR report

Telomere_length against wg lh intensity-contrast entorhinal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1585039	0.1284778	0.2309423
Weighted median	23	-0.1453418	0.0560166	0.0094696
Inverse variance weighted	23	-0.1567720	0.0490518	0.0013932
Simple mode	23	-0.0987438	0.0914000	0.2916888
Weighted mode	23	-0.1528950	0.0639732	0.0258463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.07984	21	0.0276707
Inverse variance weighted	35.08020	22	0.0380040

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001063	0.0072613	0.9884537

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015562	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8