Two sample MR report

Telomere_length against wg lh intensity-contrast cuneus

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1581195	0.1398108	0.2708257
Weighted median	23	-0.0926243	0.0608669	0.1280714
Inverse variance weighted	23	-0.0781379	0.0575031	0.1741950
Simple mode	23	-0.2010736	0.1191324	0.1055746
Weighted mode	23	-0.1185397	0.0975413	0.2371420

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.54419	21	0.0047988
Inverse variance weighted	48.21146	22	0.0010174

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0145063	0.0079018	0.0805868

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015834	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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