Two sample MR report

Telomere_length against wg lh intensity-contrast caudalmiddlefrontal

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0577375	0.1476227	0.6996520
Weighted median	23	-0.2425689	0.0648174	0.0001823
Inverse variance weighted	23	-0.1812946	0.0574599	0.0016042
Simple mode	23	-0.2401937	0.1044620	0.0313523
Weighted mode	23	-0.2361006	0.0981579	0.0250085

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.31699	21	0.0011594
Inverse variance weighted	48.14053	22	0.0010396

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075864	0.0083433	0.3735208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021186	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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