Two sample MR report

Telomere_length against wg lh intensity-contrast caudalanteriorcingulate

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0748035	0.1097089	0.5027938
Weighted median	23	-0.0521190	0.0621110	0.4013984
Inverse variance weighted	23	-0.1029777	0.0419631	0.0141274
Simple mode	23	-0.0858302	0.1185309	0.4766246
Weighted mode	23	-0.0570721	0.0869904	0.5185802

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.57841	21	0.2229822
Inverse variance weighted	25.67321	22	0.2659767

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017299	0.0062005	0.7829802

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009909	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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