Two sample MR report

Telomere_length against wg lh intensity-contrast bankssts

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0893493	0.1658086	0.5956435
Weighted median	23	-0.1949774	0.0701195	0.0054251
Inverse variance weighted	23	-0.1724712	0.0637500	0.0068216
Simple mode	23	-0.3117298	0.1305851	0.0260024
Weighted mode	23	-0.2353914	0.1055710	0.0362922

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	58.43217	21	2.20e-05
Inverse variance weighted	59.25747	22	2.88e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051037	0.0093712	0.591754

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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