Two sample MR report

Telomere_length against rfMRI connectivity ICA-features 6

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1539477	0.1398436	0.2834183
Weighted median	23	0.0784438	0.0588113	0.1822619
Inverse variance weighted	23	-0.0000812	0.0551930	0.9988267
Simple mode	23	0.0805836	0.1237747	0.5217563
Weighted mode	23	0.0805836	0.0617046	0.2050575

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.21733	21	0.0052700
Inverse variance weighted	44.02779	22	0.0035183

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0094589	0.0079046	0.2447874

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013341	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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