Two sample MR report

Telomere_length against rfMRI connectivity ICA-features 5

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1445102	0.1090256	0.1992554
Weighted median	23	0.0840473	0.0599680	0.1610538
Inverse variance weighted	23	0.0793076	0.0420500	0.0592905
Simple mode	23	0.0656166	0.0914065	0.4804011
Weighted mode	23	0.0789307	0.0705751	0.2754634

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.05209	21	0.2449149
Inverse variance weighted	25.55570	22	0.2712456

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040041	0.0061627	0.522909

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008996	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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