Two sample MR report

Telomere_length against rfMRI connectivity ICA-features 4

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1131036	0.0998169	0.2699388
Weighted median	23	0.0155810	0.0601441	0.7955880
Inverse variance weighted	23	-0.0327901	0.0390148	0.4006533
Simple mode	23	0.1097841	0.1039256	0.3022611
Weighted mode	23	0.0466524	0.0929264	0.6206298

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.34006	21	0.6273943
Inverse variance weighted	19.10420	22	0.6388856

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049322	0.0056422	0.391925

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006003	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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