Two sample MR report

Telomere_length against rfMRI connectivity ICA-features 3

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0632717	0.1378384	0.6509299
Weighted median	23	0.0493686	0.0597761	0.4088657
Inverse variance weighted	23	0.0133665	0.0528299	0.8002606
Simple mode	23	0.0002627	0.0944738	0.9978063
Weighted mode	23	0.0525903	0.0579378	0.3738710

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.04267	21	0.0073484
Inverse variance weighted	40.33769	22	0.0098701

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030647	0.0077913	0.698029

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012258	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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