Two sample MR report

Telomere_length against rfMRI connectivity ICA-features 2

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0146056	0.0998201	0.8850648
Weighted median	23	-0.0428736	0.0522964	0.4123198
Inverse variance weighted	23	-0.0386938	0.0390155	0.3213166
Simple mode	23	-0.0954752	0.1017821	0.3584112
Weighted mode	23	-0.0381564	0.0674555	0.5773543

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.82746	21	0.4695237
Inverse variance weighted	20.89620	22	0.5271612

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0014793	0.0056423	0.7957434

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000663	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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