Two sample MR report

Telomere_length against rfMRI connectivity ICA-features 1

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1626189	0.0998187	0.1181927
Weighted median	23	-0.0712463	0.0581111	0.2201850
Inverse variance weighted	23	-0.0630195	0.0390154	0.1062570
Simple mode	23	-0.0801324	0.0993229	0.4284254
Weighted mode	23	-0.0916627	0.0658430	0.1777943

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.41382	21	0.7459681
Inverse variance weighted	17.58896	22	0.7300616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0061164	0.0056423	0.2906366

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006121	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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