Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 99)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0405027	0.0998208	0.6890274
Weighted median	23	-0.0134891	0.0540541	0.8029367
Inverse variance weighted	23	0.0223022	0.0390157	0.5675792
Simple mode	23	-0.0480893	0.0969720	0.6248762
Weighted mode	23	-0.0137426	0.0708051	0.8478859

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.64508	21	0.6713405
Inverse variance weighted	18.11232	22	0.6993083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038568	0.0056423	0.5017308

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005588	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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