Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 98)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0523975	0.1324062	0.6962937
Weighted median	23	-0.0210728	0.0608401	0.7290692
Inverse variance weighted	23	-0.0017104	0.0507700	0.9731251
Simple mode	23	-0.0084204	0.0970810	0.9316663
Weighted mode	23	-0.0150382	0.0653175	0.8200382

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.94925	21	0.0170613
Inverse variance weighted	37.25359	22	0.0221836

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031127	0.0074842	0.6817028

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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