Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 97)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0477339	0.0998205	0.6374504
Weighted median	23	0.0006141	0.0549816	0.9910883
Inverse variance weighted	23	0.0199452	0.0390156	0.6092029
Simple mode	23	0.0603093	0.0907659	0.5133079
Weighted mode	23	-0.0001441	0.0648700	0.9982482

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.90234	21	0.8278202
Inverse variance weighted	15.44492	22	0.8424475

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041562	0.0056424	0.4695131

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000476	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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