Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 95)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0733198	0.1372989	0.5989388
Weighted median	23	-0.0399930	0.0664856	0.5474880
Inverse variance weighted	23	-0.0372726	0.0533786	0.4850092
Simple mode	23	-0.1611375	0.1529756	0.3036111
Weighted mode	23	0.1581848	0.1135505	0.1775141

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.73302	21	0.0080126
Inverse variance weighted	41.18195	22	0.0078397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067916	0.0077609	0.3914179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012755	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8