Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 94)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1459610	0.1218678	0.2443784
Weighted median	23	0.0654500	0.0576323	0.2561037
Inverse variance weighted	23	0.0358429	0.0475941	0.4513925
Simple mode	23	0.0994293	0.0876416	0.2687958
Weighted mode	23	0.0706648	0.0588651	0.2427302

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.30134	21	0.068787
Inverse variance weighted	32.73777	22	0.065659

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067623	0.0068885	0.3374332

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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