Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 93)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0179514	0.1193116	0.8818389
Weighted median	23	-0.0026297	0.0646074	0.9675333
Inverse variance weighted	23	0.0039473	0.0456045	0.9310255
Simple mode	23	-0.0838080	0.1262569	0.5137220
Weighted mode	23	-0.0384535	0.0889276	0.6696499

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.00208	21	0.0919462
Inverse variance weighted	30.05889	22	0.1170401

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013448	0.0067441	0.8438646

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009112	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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