Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 92)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0050981	0.1076396	0.9626717
Weighted median	23	0.0144941	0.0559947	0.7957528
Inverse variance weighted	23	-0.0164618	0.0411174	0.6888906
Simple mode	23	0.0066785	0.0903164	0.9417219
Weighted mode	23	0.0131927	0.0622106	0.8340082

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.41884	21	0.2732101
Inverse variance weighted	24.43414	22	0.3248912

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006978	0.0060843	0.9097759

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007458	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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