Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 91)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.1041902 0.1004308 0.3113332
Weighted median 23 -0.0342884 0.0577072 0.5523926
Inverse variance weighted 23 -0.0254135 0.0401063 0.5263080
Simple mode 23 -0.1127356 0.1087437 0.3111328
Weighted mode 23 -0.0053233 0.0673244 0.9376919

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 21.25768 21 0.4433069
Inverse variance weighted 23.24742 22 0.3878732

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.007959 0.0056768 0.1755229

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007173 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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