Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 9)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0188445	0.1035848	0.8573873
Weighted median	23	0.0033793	0.0614177	0.9561218
Inverse variance weighted	23	0.0298270	0.0398007	0.4536109
Simple mode	23	-0.0055946	0.1112725	0.9603545
Weighted mode	23	-0.0234676	0.0827990	0.7794986

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.61400	21	0.3648992
Inverse variance weighted	22.89462	22	0.4077007

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029889	0.0058551	0.6150397

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007115	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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