Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 89)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0726445	0.0998207	0.4748036
Weighted median	23	-0.0425851	0.0554877	0.4428029
Inverse variance weighted	23	0.0011263	0.0390157	0.9769709
Simple mode	23	-0.1039091	0.0925994	0.2739032
Weighted mode	23	-0.0546702	0.0607774	0.3781195

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.35161	21	0.7495813
Inverse variance weighted	16.99626	22	0.7635682

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045302	0.0056423	0.4310252

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005151	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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