Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 88)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0481866	0.0998200	0.6342780
Weighted median	23	0.0706040	0.0546061	0.1960214
Inverse variance weighted	23	0.0963571	0.0390154	0.0135220
Simple mode	23	0.0812098	0.0913893	0.3838237
Weighted mode	23	0.0812098	0.0632072	0.2122191

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.24631	21	0.8103930
Inverse variance weighted	15.52118	22	0.8389186

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029582	0.0056423	0.6055744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006551	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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