Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 87)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0291758	0.1324897	0.8278326
Weighted median	23	0.0331328	0.0568756	0.5601968
Inverse variance weighted	23	-0.0089600	0.0507116	0.8597549
Simple mode	23	0.0184658	0.0918146	0.8424524
Weighted mode	23	0.0184658	0.0567327	0.7478875

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.99535	21	0.0168548
Inverse variance weighted	37.16763	22	0.0226730

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023419	0.007489	0.7575803

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011278	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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