Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 86)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0837628	0.0998210	0.4108473
Weighted median	23	0.0196072	0.0546801	0.7199090
Inverse variance weighted	23	0.0009723	0.0390157	0.9801174
Simple mode	23	0.0759891	0.0811513	0.3592398
Weighted mode	23	0.0344380	0.0600205	0.5719424

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.51410	21	0.7963006
Inverse variance weighted	16.32602	22	0.7993823

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050841	0.0056423	0.3777706

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004947	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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