Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 85)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0541539	0.1038544	0.6075158
Weighted median	23	-0.0351310	0.0540196	0.5154740
Inverse variance weighted	23	0.0037867	0.0400044	0.9245862
Simple mode	23	-0.0612171	0.0914288	0.5101052
Weighted mode	23	-0.0475104	0.0668019	0.4844252

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.73132	21	0.3584693
Inverse variance weighted	23.12899	22	0.3944767

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035581	0.0058704	0.550932

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007011	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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