Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 84)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0146647	0.0998211	0.8846047
Weighted median	23	-0.0096759	0.0541290	0.8581288
Inverse variance weighted	23	0.0150796	0.0390157	0.6991260
Simple mode	23	0.0208113	0.0874308	0.8140598
Weighted mode	23	-0.0103810	0.0635857	0.8718038

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.74512	21	0.8355203
Inverse variance weighted	14.84992	22	0.8685977

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018266	0.0056424	0.7493461

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004545	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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