Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 83)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0542721	0.1315665	0.6841487
Weighted median	23	-0.0004746	0.0635595	0.9940419
Inverse variance weighted	23	-0.0336906	0.0508691	0.5077798
Simple mode	23	-0.0399428	0.1179724	0.7381382
Weighted mode	23	-0.0399428	0.0935525	0.6735608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.48277	21	0.0192858
Inverse variance weighted	37.39935	22	0.0213756

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054018	0.0074368	0.4756359

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011559	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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