Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 82)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0353352	0.1175276	0.7666346
Weighted median	23	0.0173459	0.0582806	0.7659872
Inverse variance weighted	23	0.0345642	0.0453245	0.4457054
Simple mode	23	-0.0538775	0.0995409	0.5937677
Weighted mode	23	0.0219897	0.0723534	0.7640440

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.11193	21	0.1113401
Inverse variance weighted	29.69072	22	0.1261774

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042925	0.0066432	0.5251816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009234	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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