Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 81)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0842274	0.1014620	0.4157995
Weighted median	23	0.0755889	0.0545199	0.1656112
Inverse variance weighted	23	0.0310595	0.0390431	0.4263122
Simple mode	23	0.1115701	0.0975001	0.2647940
Weighted mode	23	0.1012856	0.0703276	0.1638919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.69625	21	0.4171911
Inverse variance weighted	22.03110	22	0.4580334

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003265	0.0057351	0.5751891

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006868	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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