Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 80)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0554405	0.0998199	0.5844865
Weighted median	23	-0.0371374	0.0579126	0.5213499
Inverse variance weighted	23	-0.0292187	0.0390153	0.4539160
Simple mode	23	-0.1223962	0.1011427	0.2390697
Weighted mode	23	-0.0998515	0.0751306	0.1974549

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.86293	21	0.7193810
Inverse variance weighted	16.94438	22	0.7664243

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016103	0.0056423	0.7781383

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005305	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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