Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 8)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0261883	0.1095372	0.8133607
Weighted median	23	0.0907961	0.0558043	0.1037276
Inverse variance weighted	23	0.0306067	0.0418315	0.4643722
Simple mode	23	0.0769564	0.0999413	0.4494804
Weighted mode	23	0.1153546	0.0626102	0.0789322

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.28838	21	0.2348904
Inverse variance weighted	25.29069	22	0.2833765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002713	0.0061916	0.9654593

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000785	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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