Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 79)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0504937	0.1023099	0.6267558
Weighted median	23	0.0009745	0.0539863	0.9855976
Inverse variance weighted	23	0.0029475	0.0393056	0.9402232
Simple mode	23	-0.1098126	0.0967766	0.2687123
Weighted mode	23	0.0121302	0.0644651	0.8524710

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.06064	21	0.3960227
Inverse variance weighted	22.32843	22	0.4404379

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029198	0.005783	0.6188934

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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