Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 78)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1567838	0.1158994	0.1905196
Weighted median	23	-0.0046863	0.0584185	0.9360631
Inverse variance weighted	23	0.0096642	0.0462193	0.8343751
Simple mode	23	0.0744240	0.1057876	0.4891095
Weighted mode	23	0.0085627	0.0678277	0.9006869

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.31031	21	0.1315679
Inverse variance weighted	30.87422	22	0.0987181

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0090346	0.0065512	0.182383

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009374	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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