Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 76)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0723610	0.0998202	0.4765053
Weighted median	23	-0.0685014	0.0566571	0.2266430
Inverse variance weighted	23	-0.0467625	0.0390154	0.2306962
Simple mode	23	-0.0699030	0.0967945	0.4777909
Weighted mode	23	-0.0670301	0.0657065	0.3187482

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.73683	21	0.6655920
Inverse variance weighted	17.81445	22	0.7169309

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001572	0.0056423	0.7832698

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005833	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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