Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 75)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1540197	0.0998207	0.1377758
Weighted median	23	0.0009876	0.0554061	0.9857789
Inverse variance weighted	23	-0.0284846	0.0390158	0.4653421
Simple mode	23	0.0330780	0.0910609	0.7198845
Weighted mode	23	0.0105404	0.0666588	0.8758010

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.72837	21	0.9466621
Inverse variance weighted	13.59513	22	0.9152240

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077091	0.0056424	0.1863003

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004281	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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