Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 74)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1131451	0.0998192	0.2697790
Weighted median	23	0.0732559	0.0590312	0.2146165
Inverse variance weighted	23	0.0720803	0.0390155	0.0646779
Simple mode	23	-0.0368518	0.1058747	0.7310961
Weighted mode	23	0.1524224	0.0796585	0.0687922

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.13712	21	0.7027614
Inverse variance weighted	17.33688	22	0.7445014

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025218	0.0056423	0.6594888

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006288	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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